Intracellular trafficking of P-glycoprotein
نویسندگان
چکیده
منابع مشابه
P-glycoprotein-dependent trafficking of nanoparticle-drug conjugates.
P-gp plays a role in the cellular traffi cking of nanoscale drug carriers. In prior work, [ 8 ] we developed a gold nanoparticle delivery platform that preferentially targeted tumor stromal cells through surface presentation of macrolide small molecules, polarizing tumor associated macrophages towards an anti-tumor phenotype. Here, we use these novel nanoscale constructs to investigate the effe...
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Emery-Dreifuss muscular dystrophy (EDMD; OMIM # 310300) is an X-linked disease characterized by early contractures of the elbows, Achilles’ tendons and posterior neck, slow progressive muscle wasting and cardiomyopathy with atrioventricular conduction block (Emery and Dreifuss, 1966; Rowland et al., 1979; Emery, 1989). Positional cloning has identified a gene on chromosome Xq28 that is mutated ...
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Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2012
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2011.12.009